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During a follow-up period of5.4 years, treatment with simvastatin was associated with 26%reduction in new onset or worsening of angina and a 37% reductionin the need for revascularization.12 There was also a significantreduction in the risk of fatal and nonfatal myocardial infarction.12In the Cholesterol and Recurrent Events (CARE) study, statintherapy with pravastatin was associated with a 37% reductionin the relative risks of fatal myocardial infarction in patientswith documented myocardial infarction.13 In the atorvastatin vs.revascularization treatment (AVERT) trial, patients with stableangina associated with coronary artery disease were randomizedto receive 80 mg of atorvastatin or percutaneous coronaryintervention with or without stent implantation. McCormack E et al (2012) Synergistic induction of p53 mediated apoptosis by valproic acidand nutlin-3 in acute myeloid leukemia

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